Antiplatelet Activity
نویسندگان
چکیده
منابع مشابه
Antiplatelet activity.
How has the need to measure antiplatelet activity arisen? First, we do routinely measure hematologic or physiological surrogates for other effective secondary prevention strategies. Specifically, international normalized ratio monitoring is used to determine warfarin dosage; blood pressure is the yardstick for titration of antihypertensive agents and glycemic control using HbA1c in diabetes.1 I...
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1 Pharmacy Times is proud to publish this new column on drug interactions by the esteemed Drs. Horn and Hansten, professors of pharmacy at the University of Washington and authors of the pocketsized drug interaction booklet The Top 100 Drug Interactions: A Guide to Patient Management and the loose-leaf reference Drug Interactions Analysis and Management. This column will appear monthly, and fee...
متن کاملAntiplatelet activity should be measured routinely: no.
Antiplatelet agents such as aspirin, clopidogrel, and dipyridamole are effective in secondary stroke prevention with single agents reducing risk by 15% to 20%1–3; the addition of a second agent (eg, combining aspirin and dipyridamole) doubles this benefit.3 As with other vascular prevention strategies, eg lowering blood pressure and cholesterol, antiplatelet agents reduce, not abolish, risk. De...
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A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against ADP and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. None of the compounds showed satisfactory activity against the aggregation induced by ADP. However, satisfac...
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A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...
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ژورنال
عنوان ژورنال: Stroke
سال: 2009
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.537654